553: Naveen Jain on the Human Ecosystem and Personalised Optimization of Your Intestine Well being

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Katie: Whats up and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here at this time with my good friend, Naveen, who’s an intensely curious entrepreneur who has been taking over some large, audacious concepts to push humanity ahead. He’s the writer of the award-winning guide “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.

And his present work is in Viome Life Sciences, which was based in 2016 with a mission of creating sickness optionally available by predicting and stopping power illness by means of a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse power illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Artistic Individual by Quick Firm, High 20 Entrepreneurs, and lots of extra.

On this episode, we speak concerning the human ecosystem and customized optimization of your intestine well being and your general well being. We speak concerning the cause the intestine impacts the complete physique. Why it’s not simply genetics from our dad and mom however truly our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at delivery and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.

The distinction between DNA and gene expression. How some meals could be good for some individuals and never others, and know which is greatest for you, but in addition, the universally dangerous meals. Why there are some universality dangerous ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The true cause it’s vital to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible data on this episode. Additionally, a number of hyperlinks to study extra within the present notes at wellnessmama.fm, so examine these out. However with out additional ado, let’s be part of Naveen Jain. Naveen, welcome again.

Naveen: Properly, Katie, so good to see you lastly after a protracted, very long time.

Katie: I’m so excited we get to have a dialog and get to file it and share it at this time, and we’re gonna speak quite a bit about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I’d say you’re the one particular person I do know in actual life who has a Moon rock assortment. And so, I’d love so that you can simply speak about this as a result of I feel you’re my solely hobbyist Moon rock collector.

Naveen: Properly, I feel, Katie, you realize, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a approach of expressing that there’s nothing that’s unimaginable for us to do. Despite the fact that it’s known as “Moonshots” that folks thought was tough, if not unimaginable to do and having, you realize, now to have the ability to go to the Moon and to me, the gathering of area rocks truly was simply merely a interest of capable of maintain one thing in your hand. Which may be even earlier than the delivery of our planet. And it provides you some thought of how fragile we’re that if we don’t deal with ourselves, our planet, we as humanity might not survive. As a species, we might not survive.

So, you realize, thought of when somebody says, “I’m actually fearful about our planet,” ask the planet and planet will let you know, “Don’t you are worried about me as a result of we…” Planet will just do effective however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing outdoors us goes unsuitable, we as inside ecosystem may also be impacted, proper. And that’s coming all the way down to, you realize, for those who take a look at what’s above, so under is absolutely what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.

Katie: I really like that you simply mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you realize him as effectively. And I requested him that query. You realize, your technology’s gonna face quite a bit within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re truly asking the unsuitable query as a result of the…”

Naveen: Oh, I like it, I like it.

Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we must be asking how we could be extra synergistic inside an surroundings that’s larger than us.”

Naveen: That’s the excellent reply. That’s precisely how I’d see it that…you realize, when individuals say, “Aren’t you fearful concerning the planet?” I say, “That’s not the query you need to be asking.” It’s, “Are we fearful concerning the human species?” That’s what we needs to be asking.

Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I’d say not fearful about however working to resolve. My listeners are fairly well being savvy and perceive or at the very least have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…effectively, we’ve identified points of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of corporations like Viome, we now have many extra tangible instruments to truly perceive and begin to do one thing about that. However to start out broad, sort of give us an outline of what we imply by the well being of the intestine impacts the well being of the entire physique.

Naveen: So, effectively, to begin with, you realize, let’s simply begin from the start. We as human beings are usually not merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which are truly expressed in our human physique are usually not our personal. They arrive from these microbes which are in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such when it comes to all of the genes which are expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re residing of their world. They don’t reside in our world, proper.

So, after we perceive that, you realize, despite the fact that you may argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you may argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and comfy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I feel that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is stuffed with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Which means it’s to create the ecosystem inside us.

Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by means of the delivery canal, that is the primary publicity the newborn will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by means of delivery canal. And sadly, a few of the moms for apparent causes find yourself getting a C-section. They really…the infants are usually not going by means of the identical…they’re uncovered to pores and skin microbiome quite by means of the delivery canal, the microbiome that they might get by means of the delivery canal. And that may be a essentially…the newborn, when it’s born, is definitely…the character has created in a approach that the microbes get launched into the newborn on the time of the delivery and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.

And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I feel that is the elemental half that folks want to know. Seventy p.c of our immune system is alongside our intestine lining. In reality, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a good friend and what’s a foe, proper. So, in some sense, for those who take a look at the human physique, there’s a tube that goes by means of us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definitely begin to take a look at all alongside the traces there’s a large quantity of microbial existence there. They usually in truth are consistently interacting with our immune system and the immune system is now understanding when there’s truly a pathogen that’s coming by means of the meals or the pathogen that’s coming by means of the surface world, react to it. And these microbes are the primary sign that tells the immune techniques, “This isn’t good. Go do one thing about it, proper.”

And I feel to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I feel as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we minimize our pores and skin or whether or not there’s some sort of pathogen or we get some sort of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are consistently in sync and wholesome and our immune system is wholesome, then our physique will truly heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique shouldn’t be comfy, you get illness which we name illness.

Katie: Yeah, so many vital factors you simply mentioned to unpack. And I feel the primary being that we actually are extra bacterial than human and also you…right here you mentioned you’re what you eat nevertheless it goes to this point past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you simply introduced up the delivery canal factor as a result of I’m a doula and I’ve truly helped in a number of C-section births with feeding the newborn, as a result of such as you mentioned, for those who don’t…the newborn is of course meant to seed their intestine by means of the delivery canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to doubtlessly disinfectants which are in that room, all types of issues. And we all know that this intestine micro organism at delivery, increasingly we study, units you up to your entire life. But additionally, the excellent news is…and I do know that Viome does a number of analysis on this. All shouldn’t be misplaced for those who don’t get an ideal begin. We now have the power to sort of get a snapshot and look within the intestine in a very distinctive approach after which optimize to enhance somebody’s well being going ahead.

And in addition, such as you mentioned, the physique’s pure state is well being. It’s not usually that we have to do something drastic. We have to get out of our personal approach and simply take away the issues which are preserving the physique from being wholesome or perhaps typically give it little additional vitamins to assist get there. Speak a bit of bit concerning the science of Viome and what we’re testing as a result of this know-how didn’t even exist a pair many years in the past, and now we now have such superb information from this.

Naveen: Properly, it’s very attention-grabbing is this concept of, you realize…for those who return and take a look at couple of many years in the past, it was truly the micro organism and all these organisms have been thought-about as an enemy of the human physique. That’s the minute you see them, your job is to kill them as rapidly as potential as a result of they’ll’t presumably be there for our good, proper. And as we began to study extra concerning the human physique, we realized that almost all of those organisms are literally commensal. They’re presupposed to be there and so they in truth…after we feed them issues like, you realize…in olden days, after we have been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the basis and eat it. That’s filled with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, truly flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.

In reality, for those who begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, for those who actually take into consideration all of the issues which are being carried out within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it truly impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or anxiousness or, you realize, you possibly can name them any names you need, you realize, a lot of these items together with autism is now linked straight into the intestine microbiome. In reality, they’ve carried out now the analysis the place they did merely a microbial transplant known as a fecal transplant and so they have been capable of in truth present that youngsters with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been capable of present if you took an individual that has a melancholy a microbial transplant or anxiousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve carried out them in mice and so they’ve carried out that in truth in people, and clearly, it was carried out by mistake however that’s truly the way it occurred.

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In reality, what’s actually attention-grabbing is habit. They usually’ve proven the identical factor. They took…there have been 17 individuals on the analysis that have been utterly hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who truly had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the habit is, proper. And I feel that’s actually phenomenal.

And now what we’re studying is each sort of most cancers…in truth what they’ve now checked out is each single stable tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide except it’s there to idiot our immune system into considering that is self and protects the tumor in opposition to the immune system attacking, proper?

Now, think about what…one other factor that’s most attention-grabbing I discovered was if you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the those who immunotherapy didn’t work, they merely have been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome shouldn’t be solely there to maintain us wholesome from all of the ailments at this time we name the totally different names. Coronary heart ailments, it’s coming from our intestine microbes truly producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In reality, we are able to now take a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites truly change the LDL manufacturing. You’re ready to take a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.

And so, anyway, the purpose I’m attempting to make is that you simply talked about one thing about these micro organism, and I simply need individuals to know the microorganisms are usually not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the most important half in truth for those who seen virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And for those who take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, in truth there are 10 occasions extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the capabilities of those micro organism that in truth modifications how these micro organism behave when it comes to what capabilities they’re performing.

So once more, what’s actually attention-grabbing is by taking a look at what organisms are there, won’t ever let you know what’s going on in your physique. In reality, their capabilities are what makes the distinction. Which means what they’re producing can…is absolutely the one factor that issues what these intestine microbes are producing, not who they’re. And I feel, Katie, you in all probability know that a number of the individuals like Akkermansia muciniphila. A number of the corporations are promoting them as a probiotic with out realizing that Akkermansia could be good for some individuals and actually it’s the primary cause for inflicting a number of sclerosis, and it has additionally been straight linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one particular person and may do one thing actually dangerous in one other particular person. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different particular person’s physique. The identical organism or similar probiotic could be good for somebody and might be dangerous for an additional particular person. And that’s the most important studying we now have had within the final six years.

Katie: Yeah, I really like that you simply introduced up the fecal microbiota switch as effectively. I’ve seen a few of the science on this and… you realize, caveat, this isn’t one thing to aim at house nevertheless it’s fairly superb what they’re conducting in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you possibly can accomplish with out having to go to that excessive if you realize what you’re working with. And for the final two years, I’ve been saying, you realize, early on in well being and wellness, I’d discover out info, learn research and be so excited and write about it, and I’ve realized increasingly over the past 15 years all the things is so customized and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You realize, I can let you know what I did nevertheless it’s not gonna work the identical for you. It may be an thought with the start line nevertheless it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”

Which is why I really like now increasingly entry to those at-home testing whether or not it’s issues like Viome, even now blood testing obtainable at house, genetic testing simply so we are able to have extra info and entry. And I’ve mentioned so many occasions on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that permit us be more practical at that may actually, actually make a distinction. So, let’s speak a bit of bit extra concerning the personalization facet of this as a result of I additionally am curious…you realize, I do know you mentioned all the things is so totally different. What’s good for one particular person is likely to be not for an additional. Are there any issues which are sort of universally dangerous that you simply’re discovering in Viome? Like, I’d put perhaps processed vegetable oils on the don’t cross record, however I’m curious what you’re seeing within the information.

Naveen: Yeah. So to begin with, it’s actually attention-grabbing. I feel you phrased it accurately. There is no such thing as a such factor as common wholesome meals. And which means there isn’t a such factor that’s good for everybody. Which means the identical meals could be good for you or dangerous for somebody. Nevertheless, there are some common unhealthy issues that you would be able to know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a kind of unhealthy issues. There is no such thing as a one who says, “The sugar is nice for me, proper.” In order that’s truly having a fried, you realize, fried meals. So, all fried stuff, it’s simply dangerous for everybody. Consuming a number of sugar, it’s simply dangerous for everybody. Nevertheless, what we discover most attention-grabbing is that analyzing the human physique and analyzing primarily based on what’s going on and what’s dynamically altering in your physique…and I feel a number of the people who find themselves listening to it, I would like individuals to know the distinction between a DNA which is static. So when individuals do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely occurring in your physique. Which means…if, Katie, you permit me, I’m gonna clarify the DNA as a result of I feel to me lots of people get very confused about what DNA is.

So, each a part of our physique is an identical DNA. Which means you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Identical DNA. And the reply is there’s…when some genes are overexpressed, some genes are beneath expressed, the identical DNA can change into eye, similar DNA can change into nail, similar DNA can change into pores and skin, similar DNA can change into coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each potential factor that may occur. And that’s one factor.

So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in the direction of the tip. As soon as we perceive all that’s occurring, we’re capable of then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to supply sulfide and the broccoli and cabbage are very excessive in sulfate so you need to minimize it down, proper.”

We will let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s truly not good for you when you’ve got excessive uric acid manufacturing. So don’t take vitamin B3 if in case you have excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nevertheless, when your bile acid manufacturing may be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume in some way taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some individuals it could do this, however for others it truly will hurt you when you’ve got excessive mobile senescence, or when you’ve got excessive inflammatory exercise. You don’t need to be taking extra NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.

So, the concept actually is that it’s a must to study what is occurring earlier than you deal with your physique like a black field. And I feel you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is occurring in our physique as a result of our major care physician…I don’t find out about you, Katie. Once I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the unwell, I’ll provide the capsule.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or for those who had any sort of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that may be a basic downside that our healthcare system has is that our medical industrial advanced, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to alter that. In my world of the longer term, Katie, we consider that…I feel identical to you simply mentioned, the way forward for healthcare goes to be delivered at house, not on the hospitals.

And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I feel COVID has been one of many…I’d say for those who look again at COVID 10 years from now, it will likely be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.

Katie: Completely. I feel so many good silver linings and educating moments in COVID and folks spent extra time at house and with their households cooking dinner at house. There have been a number of nice outcomes, as exhausting because it was for many individuals. I feel we are able to give attention to these positives. And I really like your clarification of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a bit of bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some large advances since then. So, speak about sort of the snapshot of what Viome is testing after which how persons are making modifications primarily based on that and what they’re seeing.

Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good nevertheless it didn’t inform us how these intestine modifications have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID truly, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t must go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now take a look at each your intestine well being and your human host and capable of now let you know what’s your organic age. And that tells you not solely, you realize, how effectively or how poorly your physique is growing older in comparison with your chronological age.

So, to present you an thought, I’m now gonna be 63 in September and my organic age is all the way down to 50. And that tells you that actually that my physique is performing on the stage after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra power than in truth I had after I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Which means how effectively are you protected in opposition to for those who have been to catch flu or chilly or any sort of pathogen, how effectively your physique is ready to shield itself? And that’s your immune well being. Your mobile well being. That tells you ways effectively your cells are capable of endure the issues which are occurring within the human physique. Mitochondrial well being, that’s your power manufacturing unit. How effectively the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you are feeling fatigued, you are feeling drained. We provide you with clearly your intestine well being.

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And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the way in which from high of your tube, your saliva, your stool and blood, all three on the similar time. And by taking a look at that, we’re additionally gonna be capable to present you some extra insights akin to your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna be capable to present you your oral well being akin to your gum well being, your tooth well being and all of the gum, you realize…leaky gum as a substitute of simply leaky intestine. We’ll be capable to present you ways effectively your boundaries of your gums are performing in order that microbes are usually not going into your blood.

And different factor we do now which we didn’t do till a few yr in the past is if you do a take a look at, not solely you get your deep perception what’s occurring in your physique and never simply let you know listed below are the meals which are good for you and right here is why. Listed below are the meals you need to keep away from and why. We used to let you know listed below are the dietary supplements you need to take. Now we transcend that, Katie. We’re capable of let you know you solely want 22 milligram of berberine daily. You want 17 milligram of elderberry daily. You want 79 milligram amylase daily. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.

There is no such thing as a premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the way in which, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique modifications, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of alter your…as your physique is altering, we adapt the vitamin that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.

Different issues that I’m actually, actually enthusiastic about…and we now have not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll be capable to spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable to let you know if in case you have any oral most cancers or throat most cancers. After which we’ll be capable to truly join you with a health care provider to have the ability to do one thing about it. So, in case you are above…over 50 years outdated or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable to truly at house do a take a look at and really know that you simply’re not at a danger of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.

Katie: Yeah. That is so innovative and I feel simply to spotlight what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive know-how. And since you’ve now examined hundreds and hundreds, in all probability a whole bunch of hundreds of individuals, then the algorithm has entry to all this info so it could possibly proceed to get increasingly specialised and direct with the suggestions and study your individual physique over time. So, you’re getting this type of ongoing, correct image which I feel is so fascinating.

Naveen: Yeah. So, Katie, we now have analyzed over 350,000 samples already. And that has given us this…you realize, the a part of being the…a part of that Viome ecosystem is each single one that joins profit from the opposite 350,000 samples that we now have analyzed and so they contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one that joins profit themselves and advantages the humanity on the similar time as a result of now the extra we study, the higher suggestions we are able to make for everybody. So, earlier than we simply solely might take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor will likely be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get increasingly exact as we study increasingly concerning the human physique. And our actual hope is, you realize, in my lifetime we’ll be capable to perceive what causes the onset of a power illness and what causes them to progress and to have the ability to stop them from occurring within the first place, to diagnose them early after they truly do occur, and to provide you with a treatment for these ailments. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word objective of our life.

Katie: And I really like that you simply introduced up the interplay of all of the totally different microbiomes throughout the physique as effectively and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it’s because we now have an oral microbiome. And if it will get out of steadiness in a single route or the opposite, you’re gonna find yourself with these issues. However the reply shouldn’t be sterilizing your mouth and killing all micro organism identical to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Identical factor with the intestine. And such as you mentioned, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to talk along with her about that.

However I feel, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra sort of intricate information we are able to get to make enhancements over time and naturally there can be a most cancers connection right here. You realize, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And it is a approach of…as a result of even inside a person, for those who’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in examine. We have to get blood stress in examine. We have to get weight problems measures in examine.” However the way in which to try this’s gonna be totally different for each single particular person.

Naveen: I feel it’s a metabolic and inflammatory illness. So, I imply, it’s induced…power irritation is a root reason for power ailments. Nevertheless, what causes the irritation in our physique is totally different for every particular person. So despite the fact that it’s the irritation that could be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, you realize…has this firm known as Evvy, E-V-V-Y, which appears on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single lady ought to do this as a result of that’s actually…goes to be…you realize, a number of ladies undergo by means of lots of the ailments that we as males would by no means perceive. And that to some extent is, you realize, largely reproductive organ and lots of the occasions the later analysis exhibits that vaginal microbiome is concerned in preterm delivery, within the well being of the newborn and all of the issues that you simply talked about because the child goes by means of the delivery canal. All of the issues that come out in truth are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I feel each lady needs to be doing the Evvy take a look at, proper.

Now, coming again to the belongings you talked about that, you realize, human well being is advanced however as soon as we perceive biochemical stage what’s going on, that’s the rationale as a substitute of taking a look at organisms and as a substitute of taking a look at DNA, we centered on the gene expression or RNA. We centered on what microbes are producing. Wanting on the entire physique. And I feel, Katie, I wanna level out that the merchandise that you simply construct for oral well being are a few of the greatest merchandise as a result of, to me, what’s the greatest gamechanger is individuals thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. If you kill the ecosystem in your mouth, it truly destroys the entire digestive tract. And I wanna simply emphasize, you realize, to individuals when our moms advised us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too large to go down our esophagus, proper. It was truly was if you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.

So, the primary factor is that we have to permit the oral microbiome to predigest the feed so your small gut can now take in the vitamins which are already predigested. So, when you’re…so two issues it is advisable to take into consideration right here. And one is when you’re confused and you’re consuming your meals, it doesn’t get correctly digested and right here is why. If you end up confused, you’re in a combat or flight response. And the primary factor that occurs if you’re in combat or flight response is your digestive system shuts down. Keep in mind why it was designed. If you’re working away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And for those who turned lunch for another person, it didn’t matter. And for those who survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you may digest your meals.

If you come from work and you’re confused, what can we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you need to deliver your physique from sympathetic mode into parasympathetic mode. Eliminate combat or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then if you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy methods we discovered within the historical tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you could not know that my mother and pa and our faith, they don’t eat after sundown. And I all the time marvel why would that be. And it seems as a result of it is advisable to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, in truth telling that, you realize…and that to me was actually the factor that we discovered as a part of our tradition. Truly, seems we’re very scientific.

And I wanna come again to the oral merchandise. I feel individuals must be actually occupied with oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you realize, probiotics. And the merchandise, a few of the merchandise that you’ve got, Katie, are designed to boost your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I feel everybody who’s listening to it to start out listen as a result of that’s the primary. Your mouth truly is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.

Katie: I completely agree. I feel very multifaceted however begin with the mouth is so vital. And I really like a few the belongings you simply talked about about why we don’t digest meals if we’re confused and we all know, after all, that Individuals reside in a power state of stress usually. And one factor I’ve change into keen on…you realize, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you possibly can merely do respiratory workout routines. Do some field respiratory to calm your nervous system. I really like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve discovered in my very own life that I do nice after I time restricted eat and for a very long time I’d wait and never eat until midday after which eat later within the day. And I seen after I shifted that to consuming and stopping by sundown, I really feel so a lot better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that if you’re sleeping, you could be therapeutic and your physique can get into autophagy and you’ll allocate assets to all of the pure processes the physique has in-built to maintain us wholesome.

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And I additionally wanna piggyback on what you mentioned about the identical cause we don’t wanna kill our oral microbiome is similar cause we don’t wanna kill our intestine micro organism as effectively however I nonetheless see individuals sort of hopping on the bandwagon of those actually harsh cleanses or after all individuals typically take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh influence on the intestine. And so, I’d love to speak about it. Possibly if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine difficulty associated to essentially sort of killing a few of these good micro organism. Clearly, Viome helps with this however sort of, like, what could be carried out? How can we assist repair it?

Naveen: So, very first thing is, you realize, earlier than you go begin taking a number of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And then you definitely begin to take a look at what you…you realize, we let you know what are the meals you need to eat. And once more, taking a number of the fermented meals particularly if you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues needs to be diversification. So as a substitute of simply taking one sort of probiotics, you need to be taking kombucha, the kimchi, the…you realize, all of the fermented meals you possibly can presumably get your palms on. So, whether or not it’s a yogurt or, you realize, at the very least oat milk yogurt for those who can. I imply, I’m an enormous fan that I feel dairy…in truth for lots of the individuals, dairy is the massive downside. Now I’m not saying it’s for everybody however a number of the individuals, dairy might be an enormous downside. And the mammalian merchandise truly might be an enormous downside for some individuals and never for others.

So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat pink meat for all of their life and reside to be 100, and the rationale for that’s pink meat comprises clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the guts illness. So, it’s not the pink meat that causes the guts illness. It’s the byproduct of how the pink meat is digested in some those who produce TMA. So, in case your TMA manufacturing is low, you need to eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and entire class of meals.

One other factor that we discovered…we revealed a paper having analyzed over 100,000 individuals at the moment on growing older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you realize, keto food plan or paleo food plan have been the worst offender of their organic age. The individuals who have been on keto food plan in truth have been three to 5 years older than their chronological age and the identical is true for paleo food plan. It seems that people who find themselves on balanced food plan, which means they have been consuming their carbs however not quite a bit however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats and so they have been consuming the protein, they have been way more balanced, have been truly higher off biologically than reducing out the entire nutrient group utterly.

Katie: That is smart, that we want the range. And I’ve discovered increasingly as effectively that I feel the simplistic model all of us discovered, hopefully discovered in class was about simply sort of energy in, energy out. And I’ve heard it mentioned, you realize, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and vital than that.

And what’s subsequent for Viome? I’m curious as a result of I do know you’re consistently doing analysis right here, and such as you mentioned, your objective is to sort out power illness in its entirety. So, what’s within the pipeline for you guys?

Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly exact for each particular person since we make it for every particular person. We’re, you realize, attempting to do extra assessments now and our objective is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can not see within the blood as a result of they’re produced someplace else. So, can we measure issues, you realize, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict if in case you have a leaky intestine by taking a look at LBP, by taking a look at CRP which truly is finished within the liver? So, we’re going to have the ability to truly measure extra issues along with simply those that we’re measuring, and the extra info we are able to study, the higher suggestions we make. So, our hope is to proceed to launch these assessments that give us higher and higher insights and which means we are able to make increasingly exact advice for every particular person.

Final objective actually is to know…as you say, the human physique is a chemistry lab. We have now mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to know that the gene expression tells you what biochemistry is occurring within the physique. And that’s a cause…and actually, Viome is the one firm that does take a look at the gene expression as a result of there isn’t a different firm that has this know-how. And I feel individuals who have listened to your earlier podcast, we talked about, this explicit know-how got here out of Los Alamos Nationwide Lab the place they’d the laboratory for biodefense challenge. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of assets to develop this know-how. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this know-how to assist the humanity get higher. And if our mission was merely to generate income, we’d not have been capable of license this know-how, proper.

So, the actual fact at this time we’re merely centered on making each single particular person be higher. You realize, our mission on day one was what if we might perceive the human biology at a molecular stage so we are able to stop, diagnose early and treatment these power ailments together with most cancers and growing older? And I feel a number of the individuals who have heard you and I speak prior to now, you realize that I misplaced my dad to most cancers and that was one of many greatest motivator for me as a result of if I had began this firm half a decade earlier than I did, I might have doubtlessly saved my dad. And, you realize, having watched him undergo that ache or struggling by means of most cancers I noticed that despite the fact that I couldn’t save him, I might dedicate my life to saving everybody else. And that will likely be my approach of letting him know that, you realize, I’m so happy with what he…how he raised us as a baby and giving us all the things we now have so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, anxiousness or most cancers.

And my hope actually is that in our lifetime we’ll completely eradicate most cancers from the human physique. And if I have been to make a prediction at this time, I’ll let you know inside a decade I feel we’ll do away with most cancers from the human physique.

Katie: That’s an enormous declare and I hope we’re on monitor for that as effectively. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m positive the power stress of the final couple of years shouldn’t be serving to that downside. So, I’m grateful that there are assets such as you, and I’ve carried out Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna make certain…I do know you’ve provided a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. You’ll find the low cost code and the hyperlink on to it there. And to ensure I respect your time, there’s a pair final questions I’d like to ask you. The primary being if there’s a guide or a lot of books which have profoundly influenced your life. And in that case, what they’re and why?

Naveen: Yeah, so the guide that actually influenced me…there’s a guide by Clayton Christensen, you realize. I really like the person and I noticed him earlier than he died. The guide he wrote, “How Will You Measure Your Life?” And to me it was such a profound guide which tells you that it’s a must to be 100% sincere. You can’t be 99% sincere as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be another excuse to make an exception. And so, it’s a must to focus your self to by no means, ever compromise in your rules that you simply stand for. And that was simply completely a wonderful guide I learn.

You realize, the guide that additionally…I imply, clearly I wrote a guide known as “Moonshots” that’s actually about making a mindset of abundance quite than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people are usually not able to doing if we truly get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they’ll’t. That when you consider one thing is unimaginable, it turns into unimaginable for you and nobody else. And so, you’re utterly in management. The one factor you possibly can’t do is what you possibly can’t think about. Every thing else is feasible.

Katie: I really like that. I do know you and I each elevate our children with that mindset and yours are older and doing superb issues out on the planet already and mine are to start with levels of that. And lastly, what parting recommendation would you want to depart with the viewers at this time? Might be associated to one thing we’ve talked about or solely unrelated.

Naveen: I’d say dream so large that folks assume you’re loopy. Which means by no means let somebody let you know that you would be able to’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self shouldn’t be about being self-conceited. Loving your self is about not in search of another person’s approval to do the issues that imply quite a bit to you. Comply with your coronary heart, comply with your intestine, hearken to your intestine and comply with what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever assume it’s work. I rise up daily at 4 a.m., and that’s my recommendation to everybody. Everytime you rise up within the morning, for those who’re not leaping out of the mattress, you need to stop what you’re doing as a result of that’s not your calling, as a result of if you discover your calling, you’ll not be mendacity down within the mattress. You leap out of the mattress with pleasure wanting to resolve that downside.

And, Katie, I simply need to reiterate, I met your youngsters and I do know I keep in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your youngsters are going to truly transfer this humanity ahead. You might be elevating these youngsters with the mindset that all the things they need to do, they’ll. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a number of occasions. Like, after we elevate our kids, we inform them, “Our love for you is unconditional however our approval shouldn’t be.” And what which means is just is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna let you know I’m happy with you except you do issues that make us happy with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It is going to be measured by what number of lives they enhance. And the humility is an indication of success as a result of for those who nonetheless have iota of conceitedness left in you, which means you’re nonetheless attempting to show one thing to your self or another person. And humility tells you not have to try this, proper. And that may be a true signal of success. And all I can say is I’m so happy with each one among your youngsters, Katie. And I can not await them to develop up and really do issues that may make our kids’s and grandchildren’s life higher.

Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over truly parenting earlier than we ever talked about well being. And we share that similarity. I inform my youngsters daily, “I really like you unconditionally and there’s nothing you ever must do to earn my love and there’s nothing you may ever do that may take away from my love.” However you’re proper. Additionally, I would like that, like, their delight to come back from inside, like…and I inform them usually, “You need to really feel actually happy with how exhausting you labored and you could…” As a result of I would like them to have that inside them and that self-love.

And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening at this time of mothers, as a result of I feel mothers have such an incredible distinctive potential to essentially shift the way forward for humanity by how we guardian our children and by serving to kind these future leaders. And for individuals who aren’t already acquainted with you, I’d encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your youngsters on their life journeys and your spouse in her personal proper is unbelievable as effectively. So very grateful to your entire household and for all that every one of you’re doing on the planet and to your time at this time. I understand how busy you’re and I’m so grateful you took the time to be right here.

Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.

Katie: And thanks, as all the time, to all of you for listening and sharing your Most worthy assets, your time, your power, and your consideration with us at this time. We’re each so grateful that you simply did. And I hope that you’ll be part of me once more on the subsequent episode of the “Wellness Mama” podcast.

 

If you happen to’re having fun with these interviews, would you please take two minutes to depart a score or evaluation on iTunes for me? Doing this helps extra individuals to search out the podcast, which suggests much more mothers and households may gain advantage from the knowledge. I actually admire your time, and thanks as all the time for listening.